Zestril tablets is one of the most selling drugs in Saudi Arabia to treat Hypertension

Zestril is one the best medication to treat Hypertension in the world market.

The active constituent:

lisinopril.



 The third introduced ACEI after captopril and enalpril.

 It has many advantages over captopril and Enalapril,as It is hydrophilic,has a long half-life,tissue penetration,and is not metabolized by the liver.
Lisinopril is typically used for the treatment of:
1-Hypertension.
2-Congestive Heart Failure.
3-Acute Myocardial Infarction.
4- Diabetic Nephropathy.

Mechanism of action:-

 Lisinopril is the lysine (Aminoacid) analogue of enalapril.

Unlike other ACE inhibitors, it is not a prodrug and is excreted unchanged in the urine.
In some cases , it can be removed from circulation by dialysis.


Zestril one of the best drugs to treat Hypertension *Lisinopril*
- Lisinopril has been contraindicated to pregnancy, Category C.

Side effect of Zestril tablets:
Nausea and vomiting.
Hypotension.

There are 3 concentration of Zestril:

Zestril 5 mg
Zestril 10 mg
Zestril 20 mg

There is also Zestoretic which contains beside lisinopril Hydrochlorothiazide which is used as diuretic.

Zestril is manufactured by AsteraZeneca Company.

wdcfawqafwef